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    Science. 2002 Feb 8;295(5557):1089-92. Epub 2002 Jan 3.

    Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning.

    Lai L, Kolber-Simonds D, Park KW, Cheong HT, Greenstein JL, Im GS, Samuel M, Bonk A, Rieke A, Day BN, Murphy CN, Carter DB, Hawley RJ, Prather RS.

    Source

    Department of Animal Science, University of Missouri, Columbia, MO 65211, USA.

    Abstract

    The presence of galactose alpha-1,3-galactose residues on the surface of pig cells is a major obstacle to successful xenotransplantation. Here, we report the production of four live pigs in which one allele of the alpha-1,3-galactosyltransferase locus has been knocked out. These pigs were produced by nuclear transfer technology; clonal fetal fibroblast cell lines were used as nuclear donors for embryos reconstructed with enucleated pig oocytes.

    PMID:
    11778012
    [PubMed - indexed for MEDLINE]

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