Send to

Choose Destination
See comment in PubMed Commons below
Immunol Invest. 2001 Nov;30(4):335-45.

Antigenicity of poly(I) and ROS-poly(I) and their recognition of human anti-DNA autoantibodies.

Author information

  • 1Department of Biochemistry, Faculty of Medicine, A.M.U., Aligarh, India.


The effect of hydroxyl radicals on polyinosinic acid [poly(I)] was studied. Strand breaks, base alteration and a decrease in absorbance at 248 nm (lambda max) were observed upon *OH modification of poly(I). The broad antigen specificity of the induced anti-poly(I) and anti-ROS-poly(I) antibodies showed diverse antigen binding characteristics similar to those of SLE autoantibodies. Recognition of both poly(I) and ROS-poly(I) by human SLE anti-DNA autoantibodies was observed. The possible significance of these findings in the etiology of SLE has been discussed.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk