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Immunol Invest. 2001 Nov;30(4):335-45.

Antigenicity of poly(I) and ROS-poly(I) and their recognition of human anti-DNA autoantibodies.

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  • 1Department of Biochemistry, Faculty of Medicine, A.M.U., Aligarh, India.

Abstract

The effect of hydroxyl radicals on polyinosinic acid [poly(I)] was studied. Strand breaks, base alteration and a decrease in absorbance at 248 nm (lambda max) were observed upon *OH modification of poly(I). The broad antigen specificity of the induced anti-poly(I) and anti-ROS-poly(I) antibodies showed diverse antigen binding characteristics similar to those of SLE autoantibodies. Recognition of both poly(I) and ROS-poly(I) by human SLE anti-DNA autoantibodies was observed. The possible significance of these findings in the etiology of SLE has been discussed.

PMID:
11777284
[PubMed - indexed for MEDLINE]
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