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Chemistry. 2001 Dec 3;7(23):5153-9.

Nanotube formation by hydrophobic dipeptides.

Author information

  • Department of Chemistry, University of Oslo, Norway. c.h.gorbitz@kjemi.uio.no

Abstract

A wide range of applications has been suggested for peptide-based nanotubes, which first attracted considerable interest as model systems for membrane channels and pores. The intriguing and unprecedented observation of nanotube formation by supramolecular self-assembly of the four dipeptides L-Leu-L-Leu, L-Leu-L-Phe, L-Phe-L-Leu and L-Phe-L-Phe is described here. These simple compounds crystallize with hydrogen-bonded head-to-tail chains in the shape of helices with four to six peptide molecules per turn. The resulting structures have chiral hydrophilic channels with a van der Waals' diameter up to 10 A.

PMID:
11775688
[PubMed - indexed for MEDLINE]
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