Cell Mol Life Sci. 2001 Nov;58(12-13):1857-78.

The protein-only theory and the yeast Saccharomyces cerevisiae: the prions and the propagons.

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Institut de Biochimie et Génétique Cellulaires, Bordeaux, France.

Abstract

The yeast prions represent a very attractive and tractable model for investigating the prion world. The more extensively studied yeast prion [PSI] leads to a propagation model that links auto-aggregation in amyloid formation and inactivation of the cellular function of the yeast 'prion protein' Sup35p. The other prion model, [URE3], appears to be similar in some genetic and biochemical properties. The characterisation of both Sup35p and Ure2p, the two 'prion proteins', mainly focusing on their aggregation properties, support this model. However, some important differences still exist that should be examined carefully. In particular, we have shown that Ure2p aggregation in vivo (monitored by fluorescence of Ure2-GFP fusion) does not necessarily give rise to a [URE3] phenotype. Comparisons of these two systems as well as more recent experiments are discussed in this review.

PMID:: 11766884; [PubMed - indexed for MEDLINE]

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Cited by 1 PubMed Central article

The mechanisms of [URE3] prion elimination demonstrate that large aggregates of Ure2p are dead-end products. [EMBO J. 2003]
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Ripaud L, Maillet L, Cullin C. EMBO J. 2003 Oct 1; 22(19):5251-9.

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