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Curr Opin Investig Drugs. 2001 Nov;2(11):1564-7.

Mechanism of action of thiazolidinediones.

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  • 1Eastern Virginia Medical School, Department of Internal Medicine, Norfolk 23510, USA.


Type 2 diabetes is associated with multiple metabolic abnormalities including insulin resistance and the procoagulant state. Thiazolidenediones are an emerging class of insulin sensitizers which have the potential to mitigate many of the complications of diabetes. Mechanisms of action of the thiazolidenediones are discussed together with their possible pitfalls. Presently, evidence to clearly define the role of thiazolidenedionesfor the treatment of type 2 diabetes is lacking.

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