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Curr Opin Pharmacol. 2001 Dec;1(6):597-603.

The gastrointestinal pharmacology of cannabinoids.

Author information

  • 1Department of Experimental Pharmacology, University of Naples Federico II, Italy. aaizzo@unina.it

Abstract

The digestive tract contains endogenous cannabinoids (anandamide and 2-arachidonylglycerol) and cannabinoid CB1 receptors can be found on myenteric and submucosal nerves. Activation of CB1 receptors inhibits gastrointestinal motility, intestinal secretion and gastric acid secretion. The enteric location of CB1 receptors could provide new strategies for the management of gut disorders.

PMID:
11757815
[PubMed - indexed for MEDLINE]
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