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    Lancet. 2001 Dec 15;358(9298):2051-2.

    Interferon gamma gene polymorphism and susceptibility to, and severity of, rheumatoid arthritis.

    Constantin A, Navaux F, Lauwers-Cancès V, Abbal M, van Meerwijk JP, Mazières B, Cambon-Thomsen A, Cantagrel A.

    Abstract

    A strong association between an interferon gamma (IFN-gamma) gene polymorphism and rheumatoid arthritis susceptibility and severity has been reported in a case-control study. We investigated this polymorphism in 103 patients with early rheumatoid arthritis and 130 controls. Severity of rheumatoid arthritis was measured after 4-year follow-up with a validated radiographic score. The median radiographic score in patients increased from 1 (IQR 0-4) to 11.5 (2-35) over the 4-year follow up. The distribution of IFN-gamma alleles did not differ between patients and controls, and the distribution of radiographic scores did not differ among patients carrying the different IFN-gamma alleles. We have failed to confirm the association between the IFN-gamma gene polymorphism and rheumatoid arthritis susceptibility or severity.

    PMID:
    11755617
    [PubMed - indexed for MEDLINE]

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