Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Hematol. 2002 Jan;9(1):2-10.

Toll-like receptors: how they work and what they do.

Author information

  • 1Scripps Research Institute, La Jolla, California 92037, USA. bruce@scripps.edu

Abstract

The Toll-like receptors are the primary sensors of the innate immune system. This assignment of function was predicated on positional cloning, and was the result of long and painstaking inquiry into the mechanism of responses to bacterial endotoxin, the abundant lipopolysaccharide component of the outer membrane of Gram-negative bacteria. The sequence of events that led to the discovery of Toll-like receptor function carries an important lesson that should guide further analysis of the innate immune system.

PMID:
11753071
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk