Clin Chim Acta. 1975 Sep 1;63(2):197-204.

The determination of kynurenine in plasma.

Abstract

A method is described for the estimation of kynurenine in plasma via alkaline cleavage, extraction and diazotisation and coupling. Tryptophan interference, which is demonstrated in an earlier method, has been eliminated. Data on the specificity of the present method and the normal adult male range of fasting plasma kynurenine are presented. The time course of plasma tryptophan and kynurenine after a tryptophan load are studied in 3 subjects as an additional validation of the method, and as an example of its application. The method described is convenient and requires no complex apparatus.

PMID:: 1175292; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Molecular Biology Databases

(L)-TRYPTOPHAN - HSDB

Supplemental Content

Save items

Related citations in PubMed

Short-term and repetitive administration of oral tryptophan in normal men. Effects on blood tryptophan, serotonin, and kynurenine concentrations. [Arch Gen Psychiatry. 1981]
Short-term and repetitive administration of oral tryptophan in normal men. Effects on blood tryptophan, serotonin, and kynurenine concentrations.
Yuwiler A, Brammer GL, Morley JE, Raleigh MJ, Flannery JW, Geller E. Arch Gen Psychiatry. 1981 Jun; 38(6):619-26.
Determination of kynurenine by a simple gas-liquid chromatographic method applicable to urine, plasma, brain and cerebrospinal fluid. [J Chromatogr. 1978]
Determination of kynurenine by a simple gas-liquid chromatographic method applicable to urine, plasma, brain and cerebrospinal fluid.
Joseph MH. J Chromatogr. 1978 Jul 1; 146(1):33-41.
Increased plasma kynurenine and its relationship to neopterin and tryptophan in Tourette's syndrome. [Psychol Med. 1996]
Increased plasma kynurenine and its relationship to neopterin and tryptophan in Tourette's syndrome.
Rickards H, Dursun SM, Farrar G, Betts T, Corbett JA, Handley SL. Psychol Med. 1996 Jul; 26(4):857-62.
Plasma tryptophan, kynurenine and 3-hydroxykynurenine measurement using automated on-line solid-phase extraction HPLC-tandem mass spectrometry. [J Chromatogr B Analyt Technol ...]
Plasma tryptophan, kynurenine and 3-hydroxykynurenine measurement using automated on-line solid-phase extraction HPLC-tandem mass spectrometry.
de Jong WH, Smit R, Bakker SJ, de Vries EG, Kema IP. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Mar 1; 877(7):603-9. Epub 2009 Jan 21.
Review L-kynurenine: its synthesis and possible regulatory function in brain. [Neurochem Res. 1980]
Review L-kynurenine: its synthesis and possible regulatory function in brain.
Gál EM, Sherman AD. Neurochem Res. 1980 Mar; 5(3):223-39.

See reviews... See all...

Cited by 7 PubMed Central articles

Preliminary randomized double-blind placebo-controlled trial of tryptophan combined with fluoxetine to treat major depressive disorder: antidepressant and hypnotic effects. [J Psychiatry Neurosci. 2000]
Preliminary randomized double-blind placebo-controlled trial of tryptophan combined with fluoxetine to treat major depressive disorder: antidepressant and hypnotic effects.
Levitan RD, Shen JH, Jindal R, Driver HS, Kennedy SH, Shapiro CM. J Psychiatry Neurosci. 2000 Sep; 25(4):337-46.
Mechanism of decline in rat brain 5-hydroxytryptamine after induction of liver tryptophan pyrrolase by hydrocortisone: roles of tryptophan catabolism and kynurenine synthesis. [Br J Pharmacol. 1981]
Mechanism of decline in rat brain 5-hydroxytryptamine after induction of liver tryptophan pyrrolase by hydrocortisone: roles of tryptophan catabolism and kynurenine synthesis.
Young SN. Br J Pharmacol. 1981 Nov; 74(3):695-700.
Kynurenine metabolism in vitamin-B-6-deficient rat liver after tryptophan injection. [Biochem J. 1984]
Kynurenine metabolism in vitamin-B-6-deficient rat liver after tryptophan injection.
Takeuchi F, Shibata Y. Biochem J. 1984 Jun 15; 220(3):693-9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The determination of kynurenine in plasma.
The determination of kynurenine in plasma.
Clin Chim Acta. 1975 Sep 1 ;63(2):197-204.

PubMed
The prevalence of parasite infestation and house dust mite sensitization in Gabo...
The prevalence of parasite infestation and house dust mite sensitization in Gabonese schoolchildren.
Int Arch Allergy Immunol. 2001 Nov ;126(3):231-8.

PubMed
Purification and crystallization of the respiratory complex formate dehydrogenas...
Purification and crystallization of the respiratory complex formate dehydrogenase-N from Escherichia coli.
Acta Crystallogr D Biol Crystallogr. 2002 Jan ;58(Pt 1):160-2. Epub 2001 Dec 21 .

PubMed
Pediatric flexible bronchoscopy.
Pediatric flexible bronchoscopy.
Indian Pediatr. 2001 Dec ;38(12):1382-92.

PubMed
The vaccinia virus F12L protein is associated with intracellular enveloped virus...
The vaccinia virus F12L protein is associated with intracellular enveloped virus particles and is required for their egress to the cell surface.
J Gen Virol. 2002 Jan ;83(Pt 1):195-207.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The determination of kynurenine in plasma.

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 7 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information