Active monitoring (deferred treatment or watchful waiting) in the treatment of prostate cancer. A review

Eur Urol. 2001 Nov;40(5):488-94. doi: 10.1159/000049824.

Abstract

Objectives: To evaluate the concept of active monitoring only in the management of patients with prostate cancer.

Methods: Literature review.

Results: Active monitoring may be recommended in patients with stage T1a, well- and moderately-differentiated disease. Patients with a life expectancy exceeding 10 years are recommended re-evaluation with PSA, TRUS and biopsies of the residual prostate. This treatment is also indicated in patients with stage T1b-T2b, well- and moderately-differentiated tumours and a life expectancy of less than 10 years. Active monitoring is optional in patients with stage T1b-T2b, Gleason 2-4 prostate cancer and a life expectancy of 10-15 years. It is also optional in asymptomatic patients with locally advanced disease, stage T3-T4 which are well- and moderately-differentiated and have a short life expectancy. A very rare asymptomatic patient with M1 disease and the possibility of close follow-up may be offered active monitoring.

Conclusions: Active monitoring is still a viable option for selected patients diagnosed with prostate cancer.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma / diagnosis
  • Adenocarcinoma / mortality
  • Adenocarcinoma / therapy*
  • Disease Progression
  • Humans
  • Life Expectancy
  • Male
  • Neoplasm Staging
  • Prostate-Specific Antigen / blood*
  • Prostatic Neoplasms / diagnosis
  • Prostatic Neoplasms / mortality
  • Prostatic Neoplasms / therapy*
  • Risk
  • Survival Rate
  • Treatment Outcome

Substances

  • Prostate-Specific Antigen