KLF6, a candidate tumor suppressor gene mutated in prostate cancer.
Narla G,
Heath KE,
Reeves HL,
Li D,
Giono LE,
Kimmelman AC,
Glucksman MJ,
Narla J,
Eng FJ,
Chan AM,
Ferrari AC,
Martignetti JA,
Friedman SL.
Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, Room 1170F, Box 1123, New York, NY, 10029, USA.
Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor of unknown function. Here, we show that the KLF6 gene is mutated in a subset of human prostate cancer. Loss-of-heterozygosity analysis revealed that one KLF6 allele is deleted in 77% (17 of 22) of primary prostate tumors. Sequence analysis of the retained KLF6 allele revealed mutations in 71% of these tumors. Functional studies confirm that whereas wild-type KLF6 up-regulates p21 (WAF1/CIP1) in a p53-independent manner and significantly reduces cell proliferation, tumor-derived KLF6 mutants do not. Our data suggest that KLF6 is a tumor suppressor gene involved in human prostate cancer.
PMID: 11752579 [PubMed - indexed for MEDLINE]