Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Struct Biol. 2001 Dec;11(6):746-51.

Bacterial and mammalian HMG-CoA reductases: related enzymes with distinct architectures.

Author information

  • Howard Hughes Medical Institute and Department of Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA. Istvan@borcim.wustl.edu


The committed step in the biosynthesis of isoprenoids is catalyzed by HMG-CoA reductase. Recently determined structures of the distantly related bacterial and mammalian HMG-CoA reductases have revealed two distinct classes of the protein with differently formed active sites and oligomeric states. An appreciation of the remarkable differences in the active site architecture may ultimately lead to the development of novel antibacterial agents.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk