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Brain Res Bull. 2001 Nov 15;56(5):479-85.

Serotonin and brain development: role in human developmental diseases.

Author information

  • Program in Biopsychology, Department of Psychology, SUNY at Stony Brook, 11794-2500, USA. whitaker@psych1.psy.sunysb.edu


Serotonin is known to play a role in brain development prior to the time it assumes its role as a neurotransmitter in the mature brain. Serotonin regulates both the development of serotonergic neurons (termed autoregulation of development) and the development of target tissues. In both cases, the astroglial-derived protein, S-100beta plays a role. Disruption of serotonergic development can leave permanent alterations in brain function and behavior. This may be the case in such human developmental illnesses as autism and Down Syndrome.

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