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Cell. 2001 Dec 14;107(6):739-50.

Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates.

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  • 1The Molecular Sciences Institute, 2168 Shattuck Avenue, Berkeley, CA 94704, USA. colman-lerner@molsci.org

Abstract

In Saccharomyces cerevisiae, mothers and daughters have distinct fates. We show that Cbk1 kinase and its interacting protein Mob2 regulate this asymmetry by inducing daughter-specific genetic programs. Daughter-specific expression is due to Cbk1/Mob2-dependent activation and localization of the Ace2 transcription factor to the daughter nucleus. Ectopic localization of active Ace2 to mother nuclei is sufficient to activate daughter-specific genes in mothers. Eight genes are daughter-specific under the tested conditions, while two are daughter-specific only in saturated cultures. Some daughter-specific gene products contribute to cell separation by degrading the cell wall. These experiments define programs of gene expression specific to daughters and describe how those programs are controlled.

PMID:
11747810
[PubMed - indexed for MEDLINE]
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