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1: Planta Med. 2001 Dec;67(9):847-52.Click here to read Links

Cytotoxic mono-tetrahydrofuran ring acetogenins from leaves of Annona montana.

Wang LQ, Li Y, Min BS, Nakamura N, Qin GW, Li CJ, Hattori M.

Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan.

Further studies on leaves of Annona montana led to isolation of one iso-acetogenin, montanacin G, three pairs of acetogenins, montanacin H-J and 34-epi-montanacin H-J, together with four known acetogenins, gigantetrocins A and B, annonacin and cis-annonacin. Montanacin G belongs to the iso-acetogenin group with a terminal 2,4-trans-ketolactone unit. Montanacin H-J and 34-epi-montanacin H-J contain the rare gamma-hydroxy-gamma-methyl-gamma-lactone moiety. The cytotoxic activities of these compounds, together with previously reported acetogenins, montanacins B and C, were examined against Meth-A and LLC tumor cell lines in vitro.

PMID: 11745023 [PubMed - indexed for MEDLINE]