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Adv Drug Deliv Rev. 2001 Dec 31;53(3):307-19.

Thermosensitive polymer-modified liposomes.

Author information

  • Department of Applied Materials Science, Graduate School of Engineering, Osaka Prefecture University, 1-1, Gakuen-cho, Sakai, Osaka 599-8531, Japan. kono@ams.osakafu-u.ac.jp


Temperature-sensitive liposomes are considered to be a promising tool to achieve site-specific delivery of drugs. These liposomes have been prepared using lipids whose membranes undergo a gel-to-liquid crystalline phase transition a few degrees above physiological temperature. However, recently, temperature-sensitization of liposomes has been attempted using thermosensitive polymers. So far, functional liposomes whose contents release behavior, surface properties, and affinity to cell surface can be controlled in a temperature-dependent manner, have been developed according to this strategy. The design and function of these thermosensitive polymer-modified liposomes have been outlined in this review.

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