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Adv Drug Deliv Rev. 2001 Dec 31;53(3):285-305.

The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors.

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  • 1Department of Mechanical Engineering and Materials Science, Box 90300, Duke University, B219 Levine Science Research Center, Science Drive, Durham, NC 27708-0300, USA. david.needham@duke.edu

Abstract

Our laboratories have been working together in close collaboration for over 10 years concerning the design and performance of lipid-based drug delivery systems. Over the past 3 years we have conceived of, developed, and tested pre-clinically, a new liposome-based temperature-sensitive drug delivery system for the treatment of solid tumors. This work is reported in a series of four publications: "J. Liposome Res. 9 (1999) 491; Cancer Res. Adv. Brief 60(5) (2000) 1197; Cancer Res. 6(9) (2000) 748; and Cancer Res. 60 (2000) 6950". Following a brief introduction concerning the motivations behind the work, this article will review these studies, including some of our earlier work that led to these ideas, and will present the rational design of the new liposome formulation from a materials engineering perspective.

PMID:
11744173
[PubMed - indexed for MEDLINE]
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