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Acta Pharmacol Sin. 2001 May;22(5):420-2.

Thrombolysis effect with FIIa from Agkistrodon acutus venom in different thrombosis model.

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  • 1Department of Pharmacology, Sun Yat-Sen University of Medical Sciences, Guangzhou 510080, China.

Abstract

AIM:

A fibrinolytic enzyme from Agkistrodon acutus venom, called FIIa, was tested for thrombolytic activity in animals.

METHODS:

Carotid thrombosis model in rats and rabbits and middle cerebral artery (MCA) thrombosis model in rats were used.

RESULTS:

Intravenous administration of FIIa, at a dosage of 0.625 mg/kg, resulted in thrombolysis of carotid thrombi. However, in middle cerebral artery thrombosis, the effective thrombolysis dose was 1.25 mg/kg. When the dosage of FIIa increased, the thrombolytic effect was stronger. Histological examination of kidney, liver, heart, and lung tissue showed no hemorrhage.

CONCLUSION:

It shows that FIIa from Agkistrodon acutus venom is able to solubilize thrombus in vivo without hemorrhage at an effective dose for thrombolysis.

PMID:
11743889
[PubMed - indexed for MEDLINE]
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