Nat Genet. 2002 Jan;30(1):29-30. Epub 2001 Dec 17.

Alternative splicing and genome complexity.

Brett D, Pospisil H, Valcárcel J, Reich J, Bork P.

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Max Delbrück Center for Molecular Medicine, Robert-Rössle Strasse 10, Berlin-Buch, 13125 Germany.

Abstract

Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. It has recently been proposed as a mechanism by which higher-order diversity is generated. Here we show, using large-scale expressed sequence tag (EST) analysis, that among seven different eukaryotes the amount of alternative splicing is comparable, with no large differences between humans and other animals.

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Estimating rates of alternative splicing in mammals and invertebrates. [Nat Genet. 2004]
Estimating rates of alternative splicing in mammals and invertebrates.Kim H, Klein R, Majewski J, Ott J. Nat Genet. 2004 Sep; 36(9):915-6; author reply 916-7.

PMID:: 11743582; [PubMed - indexed for MEDLINE]

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