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Nat Genet. 2002 Jan;30(1):25-6. Epub 2001 Dec 17.

Small changes in expression affect predisposition to tumorigenesis.

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  • 1The Howard Hughes Medical Institute, The Oncology Center, and The Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.


We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.

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