Involvement of benzodiazepine binding sites in an antiaggressive effect by 5-HT(1A) receptor activation in isolated mice

Eur J Pharmacol. 2001 Dec 7;432(2-3):163-6. doi: 10.1016/s0014-2999(01)01511-4.

Abstract

The effect of the benzodiazepine receptor antagonist flumazenil was examined on an antiaggressive effect of (S)-5-[3-[(1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3- benzodioxole HCl (MKC-242), a 5-HT(1A) receptor agonist. MKC-242 (0.1-1.0 mg/kg, p.o.) selectively reduced isolation-induced aggressive behavior in a dose-dependent manner. Flumazenil (10 mg/kg, i.p.) antagonized the antiaggressive effects of MKC-242 and diazepam, although it alone did not affect the behaviors of isolated mice. These findings suggest that a gamma-aminobutyric acid(A) (GABA(A)) receptor system is involved in the antiaggressive effect by 5-HT(1A) receptor activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aggression / drug effects*
  • Animals
  • Behavior, Animal / drug effects
  • Binding Sites
  • Diazepam / pharmacology
  • Dioxanes / pharmacology*
  • Dioxoles / pharmacology*
  • Dose-Response Relationship, Drug
  • Flumazenil / pharmacology
  • GABA Modulators / pharmacology
  • Male
  • Mice
  • Piperazines / pharmacology
  • Pyridines / pharmacology
  • Receptors, GABA-A / drug effects
  • Receptors, GABA-A / metabolism*
  • Receptors, Serotonin / drug effects*
  • Receptors, Serotonin / metabolism
  • Receptors, Serotonin, 5-HT1
  • Serotonin Antagonists / pharmacology
  • Serotonin Receptor Agonists / pharmacology*
  • Social Isolation

Substances

  • Dioxanes
  • Dioxoles
  • GABA Modulators
  • Piperazines
  • Pyridines
  • Receptors, GABA-A
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT1
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • Flumazenil
  • N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
  • osemozotan
  • Diazepam