Stem cells. PTEN--coupling tumor suppression to stem cells?

Science. 2001 Dec 7;294(5549):2116-8. doi: 10.1126/science.1067931.
No abstract available

Publication types

  • Comment

MeSH terms

  • Animals
  • Body Patterning
  • Brain / abnormalities
  • Brain / embryology
  • Brain / pathology
  • Brain Neoplasms / genetics
  • Brain Neoplasms / pathology
  • Cell Count
  • Cell Differentiation
  • Cell Division
  • Cell Size
  • Cell Transformation, Neoplastic
  • Embryo, Mammalian / cytology
  • Gene Targeting
  • Genes, Tumor Suppressor
  • Germ-Line Mutation
  • Humans
  • Loss of Heterozygosity
  • Mice
  • Mutation
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Neurons / cytology*
  • PTEN Phosphohydrolase
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phosphatidylinositol Phosphates / metabolism
  • Phosphoric Monoester Hydrolases / genetics*
  • Phosphoric Monoester Hydrolases / physiology*
  • Signal Transduction
  • Stem Cells / cytology*
  • Tumor Suppressor Proteins / genetics*
  • Tumor Suppressor Proteins / physiology*

Substances

  • Phosphatidylinositol Phosphates
  • Tumor Suppressor Proteins
  • phosphatidylinositol 3,4,5-triphosphate
  • Phosphatidylinositol 3-Kinases
  • Phosphoric Monoester Hydrolases
  • PTEN Phosphohydrolase
  • PTEN protein, human