Synthesis and antinephritic activities of quinoline-3-carboxamides and related compounds

Bioorg Med Chem Lett. 2002 Jan 7;12(1):85-8. doi: 10.1016/s0960-894x(01)00671-0.

Abstract

A series of linomide-related quinoline-3-carboxamides and their analogues was prepared and evaluated for antinephritic activities. The 6-MeS derivative 7a was highly effective in two nephritis models, namely chronic graft-versus-host disease and autoimmune MRL/l mice.

MeSH terms

  • Amides / chemical synthesis
  • Amides / pharmacology
  • Animals
  • Antibodies, Antinuclear / drug effects
  • Autoimmune Diseases / drug therapy
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Graft vs Host Disease / drug therapy
  • Mice
  • Mice, Inbred MRL lpr
  • Nephritis / drug therapy*
  • Proteinuria / drug therapy
  • Quinolines / chemical synthesis
  • Quinolines / pharmacology*
  • Structure-Activity Relationship

Substances

  • Amides
  • Antibodies, Antinuclear
  • Quinolines