Abstract
A series of linomide-related quinoline-3-carboxamides and their analogues was prepared and evaluated for antinephritic activities. The 6-MeS derivative 7a was highly effective in two nephritis models, namely chronic graft-versus-host disease and autoimmune MRL/l mice.
MeSH terms
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Amides / chemical synthesis
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Amides / pharmacology
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Animals
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Antibodies, Antinuclear / drug effects
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Autoimmune Diseases / drug therapy
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Drug Evaluation, Preclinical
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Graft vs Host Disease / drug therapy
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Mice
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Mice, Inbred MRL lpr
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Nephritis / drug therapy*
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Proteinuria / drug therapy
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Quinolines / chemical synthesis
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Quinolines / pharmacology*
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Structure-Activity Relationship
Substances
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Amides
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Antibodies, Antinuclear
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Quinolines