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Genome Biol. 2001;2(11):REVIEWS1030. Epub 2001 Oct 22.

HIV: master of the host cell.

Author information

  • 1Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA. littman@saturn.med.nyu.edu

Abstract

The human immunodeficiency virus has evolved various mechanisms to exploit its host cells, including the interruption and augmentation of signal transduction pathways. Recently, two DNA microarray studies have illustrated a remarkably broad-based perturbation in host transcriptional responses, which is in part mediated by the HIV-encoded Nef protein. HIV therefore seems to function as a 'master regulator' of cellular gene expression.

PMID:
11737949
[PubMed - indexed for MEDLINE]
PMCID:
PMC138982
Free PMC Article

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