Ferredoxins of the third kind.

Laboratoire de Bioénergétique Cellulaire et Pathologique, Département de Biologie Moléculaire et Structurale, CEA-Grenoble, 38054, Grenoble, France. jaques.meyer@cea.fr

Most low-potential ferredoxins (Fds) are of the well-known [2Fe-2S] plant or [4Fe-4S] bacterial type. Yet, an additional class of [2Fe-2S] Fds has been recognized on the basis of sequence and spectroscopic idiosyncrasies. A recent crystal structure has confirmed the uniqueness of this third kind of Fd, and shown that these proteins display an unexpected structural similarity to thioredoxin. The properties of these thioredoxin-like [2Fe-2S] Fds are summarized, and hypotheses concerning their function are discussed.

PMID: 11734195 [PubMed - indexed for MEDLINE]