Abstract
Two recent studies illustrate the ability of the Mre11/Rad50 DNA repair complex to bind and connect DNA ends. Specific stimulation of DNA ligase IV-mediated end-joining by Mre11 complexes from S. cerevisiae suggests the possibility of a direct role in nonhomologous end-joining in eukaryotic cells.
MeSH terms
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DNA / metabolism*
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DNA Ligase ATP
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DNA Ligases / genetics
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DNA Ligases / metabolism
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DNA Repair
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DNA-Binding Proteins*
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Endodeoxyribonucleases / chemistry*
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Endodeoxyribonucleases / genetics
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Endodeoxyribonucleases / metabolism*
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Exodeoxyribonucleases / chemistry*
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Exodeoxyribonucleases / genetics
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Exodeoxyribonucleases / metabolism*
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Fungal Proteins / chemistry*
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Fungal Proteins / genetics
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Fungal Proteins / metabolism*
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Humans
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Models, Molecular
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Protein Structure, Secondary
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Protein Structure, Tertiary
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Recombination, Genetic
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Saccharomyces cerevisiae Proteins*
Substances
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DNA-Binding Proteins
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DNL4 protein, S cerevisiae
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Fungal Proteins
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LIG4 protein, human
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RAD50 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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DNA
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Endodeoxyribonucleases
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Exodeoxyribonucleases
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MRE11 protein, S cerevisiae
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DNA Ligases
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DNA Ligase ATP