New glimpses of an old machine

Cell. 2001 Nov 30;107(5):563-5. doi: 10.1016/s0092-8674(01)00591-8.

Abstract

Two recent studies illustrate the ability of the Mre11/Rad50 DNA repair complex to bind and connect DNA ends. Specific stimulation of DNA ligase IV-mediated end-joining by Mre11 complexes from S. cerevisiae suggests the possibility of a direct role in nonhomologous end-joining in eukaryotic cells.

Publication types

  • Review

MeSH terms

  • DNA / metabolism*
  • DNA Ligase ATP
  • DNA Ligases / genetics
  • DNA Ligases / metabolism
  • DNA Repair
  • DNA-Binding Proteins*
  • Endodeoxyribonucleases / chemistry*
  • Endodeoxyribonucleases / genetics
  • Endodeoxyribonucleases / metabolism*
  • Exodeoxyribonucleases / chemistry*
  • Exodeoxyribonucleases / genetics
  • Exodeoxyribonucleases / metabolism*
  • Fungal Proteins / chemistry*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism*
  • Humans
  • Models, Molecular
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Recombination, Genetic
  • Saccharomyces cerevisiae Proteins*

Substances

  • DNA-Binding Proteins
  • DNL4 protein, S cerevisiae
  • Fungal Proteins
  • LIG4 protein, human
  • RAD50 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • DNA
  • Endodeoxyribonucleases
  • Exodeoxyribonucleases
  • MRE11 protein, S cerevisiae
  • DNA Ligases
  • DNA Ligase ATP