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J Eur Acad Dermatol Venereol. 2001 Jul;15(4):346-9.

Brooke-Spiegler syndrome.

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  • 1Department of Dermatology and Venereology, University of Medicine, Wrocław, Poland.


The Brooke-Spiegler syndrome is an autosomal dominant one characterized by cylindromas, trichoepitheliomas and occasionally spiradenomas. Within a given family, some members may have cylindromas whereas others may have trichoepitheliomas or both. We describe the coexistence of trichoepithelioma papulosum multiplex (also known as epithelioma adenoides cysticum of Brooke) and cylindromas in a 30-year-old man, and discuss the relationship between these two autosomal dominant syndromes.

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