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1: Science. 2001 Nov 30;294(5548):1875-8.Click here to read Links

Lysophospholipids--receptor revelations.

Hla T, Lee MJ, Ancellin N, Paik JH, Kluk MJ.

Center for Vascular Biology, Department of Physiology, University of Connecticut Health Center, Farmington, CT 06030-3501, USA. hla@sun.uchc.edu

Upon cell activation, membrane phospholipids are metabolized into potent lysophospholipid (LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill signaling roles in organisms as diverse as yeast and humans. The recent discovery of G protein-coupled receptors for LPs in higher eukaryotes, and their involvement in regulating diverse processes such as angiogenesis, cardiac development, neuronal survival, and immunity, has stimulated growing interest in these lipid mediators. LP receptor biology has generated insights into fundamental cellular mechanisms and may provide therapeutic targets for drug development.

PMID: 11729304 [PubMed - indexed for MEDLINE]