-
Myosin VI, a new force in clathrin mediated endocytosis.
Department of Clinical Biochemistry, University of Cambridge, UK. fb1@mole.bio.cam.ac.uk
The integrity of the actin cytoskeleton and associated motor proteins are essential for the efficient functioning of clathrin mediated endocytosis at least in polarised cells. Myosin VI, the only motor protein so far identified that moves towards the minus end of actin filaments, is the first motor protein to be shown to associate with clathrin coated pits/vesicles at the plasma membrane and to modulate clathrin mediated endocytosis. Recent kinetic studies suggest that myosin VI may move processively along actin filaments providing clues about its functions in the cell. The possible role(s) of myosin VI in the sequential steps involved in receptor mediated endocytosis are discussed.
PMID: 11728438 [PubMed - indexed for MEDLINE]
-
Cited by 8 PubMed Central articles
-
A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells.
Hertzano R, Shalit E, Rzadzinska AK, Dror AA, Song L, Ron U, Tan JT, Shitrit AS, Fuchs H, Hasson T, et al.
PLoS Genet. 2008 Oct 3; 4(10):e1000207. Epub 2008 Oct 3.
[PLoS Genet. 2008]
-
ReviewHow are the cellular functions of myosin VI regulated within the cell?
Buss F, Kendrick-Jones J.
Biochem Biophys Res Commun. 2008 Apr 25; 369(1):165-75. Epub 2007 Dec 7.
[Biochem Biophys Res Commun. 2008]
-
ReviewEndocytic trafficking of CFTR in health and disease.
Ameen N, Silvis M, Bradbury NA.
J Cyst Fibros. 2007 Jan; 6(1):1-14. Epub 2006 Nov 13.
[J Cyst Fibros. 2007]
- » See all...