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Eur J Pharmacol. 2001 Nov 16;431(2):265-8.

Hyperbaric oxygen treatment reduces carrageenan-induced acute inflammation in rats.

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  • 1Department of Underwater and Hyperbaric Medicine, Istanbul University, Istanbul Medical Faculty, 34390, Topkapi, Istanbul, Turkey.


The present study was designed to assess the anti-inflammatory activity of hyperbaric oxygen treatment by comparing it with that of diclofenac, a nonsteroidal anti-inflammatory drug, and also to investigate whether hyperbaric oxygen treatment enhances the anti-inflammatory effect of diclofenac in carrageenan-induced paw edema which is commonly employed as an acute inflammation model in rats. Hyperbaric oxygen treatment and diclofenac (20 mg/kg) markedly reduced the carrageenan-induced paw edema in rats. In other words, they displayed anti-inflammatory activity. On the other hand, hyperbaric oxygen treatment did not consistently modify the anti-inflammatory effect of diclofenac in this model.

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