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    Nat Immunol. 2001 Dec;2(12):1109-16.

    Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.

    McIntire JJ, Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS, Freeman GJ, Umetsu DT, DeKruyff RH.

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    Division of Immunology and Allergy, Department of Pediatrics and the Howard Hughes Institute, Stanford University, Stanford, CA 94305-5208, USA.

    Abstract

    To simplify the analysis of asthma susceptibility genes located at human chromosome 5q23-35, we examined congenic mice that differed at the homologous chromosomal segment. We identified a Mendelian trait encoded by T cell and Airway Phenotype Regulator (Tapr). Tapr is genetically distinct from known cytokine genes and controls the development of airway hyperreactivity and T cell production of interleukin 4 (IL-4) and IL-13. Positional cloning identified a gene family that encodes T cell membrane proteins (TIMs); major sequence variants of this gene family (Tim) completely cosegregated with Tapr. The human homolog of TIM-1 is the hepatitis A virus (HAV) receptor, which may explain the inverse relationship between HAV infection and the development of atopy.

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    PMID:
    11725301
    [PubMed - indexed for MEDLINE]

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