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Rheum Dis Clin North Am. 2001 Nov;27(4):799-813, vi-vii.

Clinical use of serological tests for antineutrophil cytoplasmic antibodies. What do the studies say?

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  • Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark. aw@ssi.dk


Trustworthy and clinically useful laboratory test results depend on high quality laboratory knowledge and performance and on close collaboration with experienced clinicians. Just like a diagnosis can only be made by contrasting it to a number of differential diagnoses, a prototype autoantibody profile can only be recognized if autoantibodies that partially mimic the former are just as well-known. In antineutrophil cytoplasmic antibody (ANCA)-associated small vessel vasculitides the characteristic autoantibody profile can only be demonstrated by use of at least two different methodologies and an assay-specific cut-off selection that clearly distinguishes between strongly positive and disease control low positive to negative values. Local serum banks containing samples from patients with well-characterized chronic immunoinflammatory diseases and ANCA-associated vasculitides are needed for such important studies whether in-house or commercial assays are used.

[PubMed - indexed for MEDLINE]
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