Neurology. 2001 Nov 27;57(10):1923-5.

Apolipoprotein E and age at onset of Alzheimer's disease in African American patients.

Goldstein FC, Ashley AV, Gearing M, Hanfelt J, Penix L, Freedman LJ, Levey AI.

Source

Department of Neurology, Emory University School of Medicine, Atlanta, GA 30329, USA. fgoldst@emory.edu

Abstract

The authors examined whether the APOE-epsilon4 allele is associated with an earlier age at onset of AD in 71 African American patients with probable AD. The authors found a linear dose effect in which each copy of the epsilon4 allele was associated with a 3.6-year earlier onset of AD, indicating a dose-dependent relationship between APOE-epsilon4 and age at onset of AD in African Americans.

PMID:: 11723294; [PubMed - indexed for MEDLINE]

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