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Neurology. 2001 Nov 27;57(10):1896-9.

Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.

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  • 1deCODE genetics Inc, Reykjavík, Iceland.


The neuroexcitatory peptide hypocretin and its receptors are central to the pathophysiology of both human and animal models of the disease. In this study of American and Icelandic patients with narcolepsy, the authors found no significant association between narcolepsy and single-nucleotide polymorphisms in the genes for hypocretin or its two known receptors, hypocretin receptor-1 and hypocretin receptor-2.

[PubMed - indexed for MEDLINE]
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