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    Diabetes. 2001 Dec;50(12):2879-82.

    Diabetes-associated HLA-DQ genes and birth weight.

    Stene LC, Magnus P, Rønningen KS, Joner G.

    Section of Epidemiology, Department of Population Health Sciences, National Institute of Public Health, Oslo, Norway. lars.christian.stene@folkhelsa.no

    An association has recently been described between increased birth weight and increased risk of childhood-onset type 1 diabetes. Whether this relationship is explained by genes associated with both increased birth weight and increased risk of type 1 diabetes is unknown. In the present study, we tested the association between birth weight and HLA-DQ genotypes known to confer risk for type 1 diabetes among 969 nondiabetic children randomly selected from the Norwegian population. We found that HLA genotypes previously shown to confer risk for type 1 diabetes were associated with reduced birth weight (the mean difference in birth weight between the DQB1*0602/DQB1*0602 and DQ8/DQ2 genotypes was 354 g [95% CI 105-604]), which was opposite of that expected if HLA genes explained the birth weight-type 1 diabetes association.

    PMID: 11723075 [PubMed - indexed for MEDLINE]

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