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Neurosci Lett. 2001 Dec 4;316(1):9-12.

Grafting neural stem cells improved the impaired spatial recognition in ischemic rats.

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  • 1Department of Neurosurgery, Clinical Neuroscience, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, 606-8507, Japan.


To determine the possible therapeutic potential of neural stem cells (NSCs) introduced into the damaged central nervous system, we grafted adult hippocampus-derived NSCs into the hippocampus of rats with transient global ischemia. Transient four-vessel occlusion yielded 90-95% losses of pyramidal neurons in the hippocampal CA1 region. In this region, 1-3% of the grafted cells survived; and 3-9% of them expressed NeuN, a neuronal marker. Rats with more than 120 NeuN-positive cells showed partial improvement of impaired spatial learning in a water maze test. These results suggest that NSCs grafted in the ischemic brain are able to differentiate into neurons and to improve spatial recognition.

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