Abstract
The recently determined crystal structure of the Ku heterodimer, in both DNA-bound and unbound forms, has shed new light on the mechanism by which this protein fulfills its key role in the repair of DNA double-strand breaks.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens, Nuclear*
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DNA / chemistry
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DNA / metabolism
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DNA Helicases*
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DNA Repair*
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DNA-Binding Proteins / chemistry*
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DNA-Binding Proteins / metabolism
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Dimerization
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Humans
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Ku Autoantigen
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Nuclear Proteins / chemistry*
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Nuclear Proteins / metabolism
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Nucleic Acid Conformation
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Protein Structure, Secondary
Substances
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Antigens, Nuclear
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DNA-Binding Proteins
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Nuclear Proteins
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DNA
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DNA Helicases
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XRCC5 protein, human
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Xrcc6 protein, human
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Ku Autoantigen