Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
J Exp Clin Cancer Res. 2001 Sep;20(3):327-34.

Gut-endocrinomas (carcinoids and related endocrine variants) of the uterine cervix: an analysis of 205 reported cases.

Author information

  • 1Niigata Seiryo University, Niigata City, Japan. soga@n-seiryo.ac.jp


This study was carried out statistically to evaluate the present situation of carcinoids and related endocrine variants in the uterine cervix. A total of 205 patients who had been reported on in world-wide literature were divided into two groups; one, as a carcinoid group, consisting of 81 patients with carcinoids, 49 typical and 32 atypical, and the others, as an endocrine carcinoma (ECC) group, including 124 patients with other remaining endocrine carcinomas variously expressed up to date. A statistical comparison in multiple factors was attempted between these two groups. A statistically significant difference between them was demonstrated in immunochemistry for chromogranin (p<0.05), serotonin (p<0.01), and CEA (p<0.01), but not regarding average age, clinical manifestations, tumor-size categorization, rates of metastases, sites of metastases, argyrophilia or argent affinity, and postoperative five-year survival rates, though the latter disclosed a statistically significant difference (p<0.05) only between the two groups of typical and atypical carcinoids. The results of analysis in the present study disclosing no statistically significant differences in various aspects between the two groups of carcinoids and the remaining endocrine carcinomas strongly suggest that the considerable extent of confusion produced by various different types of terminology for carcinoids and related endocrine variants should be solved by extensive evaluation and discussion on an international scale, and that diagnostic criteria and simplified classification acceptable for these neoplasms are to be established not only for those of the uterine cervix but also for those of all other organs including the digestive system based on a universally acceptable concept for these neoplasms originating in non-endocrine organs.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk