Send to

Choose Destination
See comment in PubMed Commons below
J Immunol. 2001 Dec 1;167(11):6441-6.

Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes.

Author information

  • 1Institute of Biochemistry, Swiss Federal Institute of Technology (Eidgenössiche Technische Hochschule), Zurich, Switzerland.


Signal sequences of human MHC class I molecules are a unique source of epitopes for newly synthesized nonclassical HLA-E molecules. Binding of such conserved peptides to HLA-E induces its cell surface expression and protects cells from NK cell attack. After cleavage from the pre-protein, we show that the liberated MHC class I signal peptide is further processed by signal peptide peptidase in the hydrophobic, membrane-spanning region. This cut is essential for the release of the HLA-E epitope-containing fragment from the lipid bilayer and its subsequent transport into the lumen of the endoplasmic reticulum via the TAP.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk