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Curr Opin Pharmacol. 2001 Jun;1(3):230-4.

Anti-leukotrienes for asthma.

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  • 1Asthma, Allergy, and Airway Research Center, Division of Pulmonary, Allergy, and Critical Care Medicine, Pittsburgh, PA 15213, USA. calhounwj@msx.upmc.edu

Abstract

The field of cysteinyl leukotriene research has moved forward considerably in the past two years. Significant recent advances have been made in three areas: genetic control of the cysteinyl leukotriene response, in which alterations in both the promoter region and in transcribed mRNA have been described; the mechanisms by which cysteinyl leukotrienes promote the development of inflammation; and extensions in the clinical arena that support broader positioning of leukotriene modifiers in the therapy of asthma and allergic diseases.

PMID:
11712744
[PubMed - indexed for MEDLINE]
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