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The role of galanin as a multi-functional neuropeptide in the nervous system.
Department of Medicine, Bristol University, UK.
The neuropeptide galanin is expressed developmentally in the DRG and is rapidly up-regulated 120-fold after peripheral nerve section in the adult. The generation and study of galanin knockout mice has indicated that the peptide is critical to the development and function of specific subsets of neurons in the central and peripheral nervous system. These data have important implications for the understanding, and potential therapeutic treatment, of sensory neuropathies and a number of neurological diseases, including Alzheimer's disease and epilepsy.
PMID: 11712539 [PubMed - indexed for MEDLINE]
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Cited by 5 PubMed Central articles
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Characterization of rodent models of HIV-gp120 and anti-retroviral-associated neuropathic pain.
Wallace VC, Blackbeard J, Segerdahl AR, Hasnie F, Pheby T, McMahon SB, Rice AS.
Brain. 2007 Oct; 130(Pt 10):2688-702. Epub 2007 Aug 30.
[Brain. 2007]
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Involvement of galanin receptors 1 and 2 in the modulation of mouse vagal afferent mechanosensitivity.
Page AJ, Slattery JA, Brierley SM, Jacoby AS, Blackshaw LA.
J Physiol. 2007 Sep 1; 583(Pt 2):675-84. Epub 2007 Jul 12.
[J Physiol. 2007]
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Modulation of gastro-oesophageal vagal afferents by galanin in mouse and ferret.
Page AJ, Slattery JA, O'donnell TA, Cooper NJ, Young RL, Blackshaw LA.
J Physiol. 2005 Mar 15; 563(Pt 3):809-19. Epub 2005 Jan 6.
[J Physiol. 2005]
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