Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Philos Trans R Soc Lond B Biol Sci. 2001 Nov 29;356(1415):1755-9.

RNA-binding proteins and circadian rhythms in Arabidopsis thaliana.

Author information

  • Institute for Plant Sciences, ETH Zurich, CH-8092 Zurich, Switzerland. dorothee.staiger@ipw.biol.ethz.ch

Abstract

An Arabidopsis transcript preferentially expressed at the end of the daily light period codes for the RNA-binding protein AtGRP7. A reverse genetic approach in Arabidopsis thaliana has revealed its role in the generation of circadian rhythmicity: AtGRP7 is part of a negative feedback loop through which it influences the oscillations of its own transcript. Biochemical and genetic experiments indicate a mechanism for this autoregulatory circuit: Atgrp7 gene transcription is rhythmically activated by the circadian clock during the day. The AtGPR7 protein accumulates with a certain delay and represses further accumulation of its transcript, presumably at the post-transcriptional level. In this respect, the AtGRP7 feedback loop differs from known circadian oscillators in the fruitfly Drosophila and mammals based on oscillating clock proteins that repress transcription of their own genes with a 24 h rhythm. It is proposed that the AtGRP7 feedback loop may act within an output pathway from the Arabidopsis clock.

PMID:
11710982
[PubMed - indexed for MEDLINE]
PMCID:
PMC1088551
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk