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1: Dev Cell. 2001 Nov;1(5):590-2.Click here to read Links

Regulated intramembrane proteolysis takes another twist.

Huppert S, Kopan R.

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Rhomboid, a seven-transmembrane domain protein, has been shown genetically to potentiate EGFR signaling via the TGFalpha-like ligand Spitz. Here we discuss recently published papers that identify Rhomboid as a novel serine protease, cleaving Spitz within its transmembrane domain.

PMID: 11709178 [PubMed - indexed for MEDLINE]