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    Dev Cell. 2001 Nov;1(5):590-2.

    Regulated intramembrane proteolysis takes another twist.

    Huppert S, Kopan R.

    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA.

    Rhomboid, a seven-transmembrane domain protein, has been shown genetically to potentiate EGFR signaling via the TGFalpha-like ligand Spitz. Here we discuss recently published papers that identify Rhomboid as a novel serine protease, cleaving Spitz within its transmembrane domain.

    PMID: 11709178 [PubMed - indexed for MEDLINE]

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