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Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13784-9. Epub 2001 Nov 13.

Diversity of gene expression in adenocarcinoma of the lung.

Author information

  • 1Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.

Erratum in

  • Proc Natl Acad Sci U S A 2002 Jan 22;99(2):1098.

Abstract

The global gene expression profiles for 67 human lung tumors representing 56 patients were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors based on gene expression patterns faithfully recapitulated morphological classification of the tumors into squamous, large cell, small cell, and adenocarcinoma. The gene expression patterns made possible the subclassification of adenocarcinoma into subgroups that correlated with the degree of tumor differentiation as well as patient survival. Gene expression analysis thus promises to extend and refine standard pathologic analysis.

PMID:
11707590
[PubMed - indexed for MEDLINE]
PMCID:
PMC61119
Free PMC Article

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