Format

Send to:

Choose Destination
See comment in PubMed Commons below
Mod Pathol. 2001 Nov;14(11):1183-6.

Metaplastic carcinoma of the breast: p53 analysis identified the same point mutation in the three histologic components.

Author information

  • 1Department of Pathology, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Japan 641-0012. wang-xj@mail.wakayama-med.ac.jp

Abstract

A rare case of metaplastic carcinoma of the breast with both squamous metaplasia and cartilaginous metaplasia was reported. Histologically, the neoplasm revealed complex features, which were consisting of invasive ductal carcinoma, squamous carcinomatous component and chondrosarcomatoid component. Gradual transition of each component was recognized microscopically. p53 mutation analysis disclosed the same point mutation in three histologically different components, but not in the normal epithelium. Based on the morphologic findings, immunohistochemical findings and the p53 mutation analysis, we concluded that these three components in the tumor originated from the same duct progenitor cells.

PMID:
11706082
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk