Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2001 Nov 9;294(5545):1354-7.

CNS synaptogenesis promoted by glia-derived cholesterol.

Author information

  • 1Synapse Group and, Protein Chemistry Group, Max-Delbrück-Center for Molecular Medicine, D-13092 Berlin, Germany.

Abstract

The molecular mechanisms controlling synaptogenesis in the central nervous system (CNS) are poorly understood. Previous reports showed that a glia-derived factor strongly promotes synapse development in cultures of purified CNS neurons. Here, we identify this factor as cholesterol complexed to apolipoprotein E-containing lipoproteins. CNS neurons produce enough cholesterol to survive and grow, but the formation of numerous mature synapses demands additional amounts that must be provided by glia. Thus, the availability of cholesterol appears to limit synapse development. This may explain the delayed onset of CNS synaptogenesis after glia differentiation and neurobehavioral manifestations of defects in cholesterol or lipoprotein homeostasis.

Comment in

PMID:
11701931
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for Faculty of 1000
    Loading ...
    Write to the Help Desk