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Cell. 2001 Nov 2;107(3):323-37.

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.

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  • 1Research Institute of Molecular Pathology (IMP), Vienna Biocenter, Dr. Bohrgasse 7, A-1030, Vienna, Austria.

Abstract

Histone H3 lysine 9 methylation has been proposed to provide a major "switch" for the functional organization of chromosomal subdomains. Here, we show that the murine Suv39h histone methyltransferases (HMTases) govern H3-K9 methylation at pericentric heterochromatin and induce a specialized histone methylation pattern that differs from the broad H3-K9 methylation present at other chromosomal regions. Suv39h-deficient mice display severely impaired viability and chromosomal instabilities that are associated with an increased tumor risk and perturbed chromosome interactions during male meiosis. These in vivo data assign a crucial role for pericentric H3-K9 methylation in protecting genome stability, and define the Suv39h HMTases as important epigenetic regulators for mammalian development.

PMID:
11701123
[PubMed - indexed for MEDLINE]
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