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Drug Dev Ind Pharm. 2001 Sep;27(8):877-84.

Hydrogels formed by cross-linked polyvinylalcohol as colon-specific drug delivery systems.

Author information

  • 1Department of Pharmaceutical Sciences, Bologna University, Italy. orienti@biocfarm.unibo.it

Abstract

Polyvinivlalcohol (PVA, of different molecular weights was cross-linked with succinyl, adipoyl, or sebacoyl chloride to obtain hydrogel-forming polymers and to determine their suitability as colon-specific drug delivery systems. Diclofenac sodium, propranolol hydrochloride, and vitamin B6 hydrochloride were used as hydrophilic model drugs with colon-specific release that should yield high concentrations in the large intestine, minimizing release in the upper part of the gastrointestinal tract. Spray -dried mixtures of the drugs and the polymer (at a 1:2 w/w ratio) were prepared, and the release of the drugs from the mixtures was evaluated in vitro at pH 2.0, 5.5, and 7.4. The results indicated the ability of the cross-linked polymers to slow the release of the drugs analyzed with respect to the pure drug dissolution at each pH. The lengthening of the cross-linker acyl chain was noted to decrease drug release further.

PMID:
11699841
[PubMed - indexed for MEDLINE]
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