Chromosome cohesion and segregation in mitosis and meiosis

Curr Opin Cell Biol. 2001 Dec;13(6):754-61. doi: 10.1016/s0955-0674(00)00279-9.

Abstract

The faithful segregation of the genetic material into daughter cells during cell division is crucial for the production of healthy progeny. Sister chromatid cohesion and separation are fundamental to this process. Progress has been made in our molecular understanding of cohesion and mechanisms for the dissolution of cohesion have been uncovered.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins
  • Chromatids / genetics
  • Chromosomal Proteins, Non-Histone
  • Chromosome Segregation*
  • Chromosomes / genetics
  • Chromosomes / metabolism
  • Cohesins
  • Fungal Proteins
  • Humans
  • Macromolecular Substances
  • Meiosis*
  • Mitosis*
  • Models, Genetic
  • Nuclear Proteins / physiology

Substances

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • Fungal Proteins
  • Macromolecular Substances
  • Nuclear Proteins